NCT03765710

Role of Dietary Protein Intake in Elderly Adults

Role of Dietary Protein Intake on Whole Body Protein Balance in Elderly Adults

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 8 (actual)
• Sponsor: University of Arkansas · Academic / Other
• Sex: All
• Age: 60 Years
• Healthy volunteers: Accepted

Summary

The investigators examined the effects of dietary protein intake in a mixed meal at two levels of protein amount on whole body protein metabolisms in older adults.

Detailed description

The investigators determined the total anabolic response to an amount of protein intake commonly eaten with dinner (70g) as compared with the amount required to maximally stimulate muscle protein synthesis (35g). Men and women, ages \> 60 years will be studied under two levels of protein intake in mixed meals in random order (35g or 70g protein in isocaloric mixed meals). For two days prior to each stable isotope tracer study, subjects' dietary intake of calories and protein will be stabilized by providing subjects their entire diets. On the third day, a 8-hr metabolic study will be conducted in the UAMS Reynolds Institute on Aging (IOA) to determine the total anabolic response to the particular amount of beef intake, which will be repeated with the other amount of protein in mixed meal after a minimum 7-day washout interval. The investigators measured whole body protein kinetics, muscle fractional synthetic rate, and plasma amino acid profile.

Conditions

• Protein Overload

Interventions

Type	Name	Description
OTHER	Recommended protein intake	Recommended protein intake in a mixed meal contained 13% protein, 54% carbohydrate, and 33% fat.
OTHER	Elevated protein intake	Increased protein intake in a mixed meal contained 26% protein, 44% carbohydrate, and 30% fat.

Timeline

• Start date: 2015-08-01
• Primary completion: 2016-09-01
• Completion: 2016-09-01
• First posted: 2018-12-05
• Last updated: 2023-04-26