NCT03765567

Placement of Antibiotic Powder in Wounds During the Emergency Room

Placement of Antibiotic Powder in Wounds During the Emergency Room (POWDER) Study

• Status: Recruiting
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 200 (estimated)
• Sponsor: The University of Texas Health Science Center at San Antonio · Academic / Other
• Sex: All
• Age: 18 Years – 89 Years
• Healthy volunteers: Not accepted

Summary

This is the first prospective controlled study to determine whether the topical application of vancomycin powder reduces infection-related complications when applied to open fracture injuries in the acute emergency department setting.

Detailed description

Open fracture injuries are highly susceptible to infection and infection-related complications. The current routine treatment for these injuries includes the use of systemic IV antibiotics. However, open fracture injuries often have compromised blood supply, reducing the amount of antibiotic that reaches the target tissue while increasing risk of injury to non-target organs. This trial aims to evaluate the effectiveness of early application of a topical vancomycin antibiotic powder on open fracture wounds, in combination with the usual treatment, in reducing the risk of infection seen in these injuries.

Conditions

• Open Fracture

Interventions

Type	Name	Description
DRUG	Vancomycin	2 vials of Vancomycin 1g powder will be applied topically to the open fracture wound site.

Timeline

• Start date: 2020-10-05
• Primary completion: 2026-07-01
• Completion: 2027-07-01
• First posted: 2018-12-05
• Last updated: 2025-08-01

Locations

2 sites across 1 country: United States

Regulatory

• FDA-regulated drug study