NCT03761498

Is There a Microbiome Associated With Poor Growth in Preterm Infants?

• Status: Active Not Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 118 (actual)
• Sponsor: University of Texas Southwestern Medical Center · Academic / Other
• Sex: All
• Age: —
• Healthy volunteers: Not accepted

Summary

This study evaluates the relationship between growth and stool microbiota in premature infants.

Detailed description

Preterm infants often require increased caloric intake to maintain appropriate growth while in the neonatal intensive care unit (NICU). While some infants will have a clear source of need for greater calories, it is often not obvious why others require increased available calories to maintain appropriate growth. Emerging evidence suggests that patterns of gut microbiota may play a role in infant and childhood growth. We hypothesize that differences in the microbial pattern in preterm infants is related to poor growth and need for increased caloric intake. This may ultimately represent a therapeutic target to improve the growth of preterm infants in the NICU. This study aims to describe the differences in microbiome which may vary with growth pattern.

Conditions

• Growth Disorders
• Growth Failure
• Prematurity

Interventions

Type	Name	Description
OTHER	Caloric Requirement	Infants will be provided standard of care and given calories required to maintain appropriate growth per unit policies already in place.

Timeline

• Start date: 2019-07-15
• Primary completion: 2025-12-30
• Completion: 2025-12-30
• First posted: 2018-12-03
• Last updated: 2025-04-01

Locations

1 site across 1 country: United States