NCT03759405

IPS Differentiated Cardiomyocytes Vein Transplantation for Chronic Heart Failure

Myocardial Cell Vein Transplantation for Chronic Heart Failure

• Status: Unknown
• Phase: Phase 2 / Phase 3
• Study type: Interventional
• Enrollment: 3 (estimated)
• Sponsor: Beijing University of Chinese Medicine · Academic / Other
• Sex: All
• Age: 30 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

Based on the safety evaluation of primates, the best cell transplantation scheme was integrated. One patient with CHF caused by coronary heart disease, one patient with CHF caused by dilatation and one patient with CHF caused by Keshan disease were selected and treated with autologous iPS differentiated cardiomyocyte intravenous transplantation. The safety evaluation of human body was completed and combined with subjective and objective indexes respectively. Structural and functional indicators were used to evaluate the therapeutic effect of cell transplantation. The results of animal experiments confirmed the safety and effectiveness of intravenous myocardial cell transplantation, and clarified its possible mechanism.

Conditions

• Chronic Heart Failure

Interventions

Type	Name	Description
BIOLOGICAL	iPS differentiated cardiomyocytes	Repair of injured myocardium by vein transplantation with autologous iPS differentiated cardiomyocytes

Timeline

• Start date: 2022-12-31
• Primary completion: 2024-12-31
• Completion: 2024-12-31
• First posted: 2018-11-30
• Last updated: 2022-07-22

Locations

1 site across 1 country: China