Trials / Completed
CompletedNCT03759002
Association of Mean Platelet Volume and Cardiovascular Disease in Children With End Stage Renal Disease.
Association Between Mean Platelet Volume With Echocardiographic Indices and Carotid Intima Media Thickness in Children With End Stage Renal Disease.
- Status
- Completed
- Phase
- —
- Study type
- Observational
- Enrollment
- 102 (actual)
- Sponsor
- Isfahan University of Medical Sciences · Academic / Other
- Sex
- All
- Age
- 18 Years
- Healthy volunteers
- Accepted
Summary
Cardiovascular disease (CVD) is the major risk factor for death in end stage renal diseases (ESRD). Approximately 80% of ESRD patients have some degrees of left ventricular abnormalities at initiation of dialysis. Carotid intima media thickness (CIMT) has been widely accepted as an useful marker to assess CVD in ESRD children. In addition, cardiac mechanics parameters are used to evaluate cardiac function more precisely. However, measuring CIMT and cardiac mechanics parameters are expensive and difficult to perform as a routine method. Mean platelet volume (MPV) is a hematological index which shows the size of platelets. Uremic state causes inflammatory condition that affects MPV. Previous studies on people with normal renal function have shown that this parameter can also have association with CVD. However the data in children with ESRD is scarce. The aim of this study is to find a simple hematologic marker to use regularly in ESRD children finding patients at risk of CVD. Therefore, we will investigate the relationship between mean platelet volume and CIMT and cardiac mechanic parameters in children with ESRD.
Conditions
- Cardiovascular Diseases
- Carotid Intimal Media Thickness
- Left Ventricular Hypertrophy
- Mean Platelet Volume
- End Stage Renal Disease
- Hemodialysis Complication
- Peritoneal Dialysis Complication
- Children
Interventions
| Type | Name | Description |
|---|---|---|
| DIAGNOSTIC_TEST | Imaging | Imaging including Echocardiography for determining cardiac indices (ejection fraction, left ventricular mass index, strain rate, global longitudinal strain) and Doppler ultrasound for measuring carotid intima media thickness |
| OTHER | Blood sampling | Blood sampling will performed on all participants for measuring hematological parameters including MPV. |
Timeline
- Start date
- 2016-02-01
- Primary completion
- 2018-02-01
- Completion
- 2018-06-15
- First posted
- 2018-11-29
- Last updated
- 2018-11-29
Source: ClinicalTrials.gov record NCT03759002. Inclusion in this directory is not an endorsement.