NCT03756948

Viscoelastic Tests-Guided Therapy In Liver Transplantation

Association Between Viscoelastic Tests-Guided Therapy With Synthetic Factor Concentrates And Allogenic Blood Transfusion In Liver Transplantation: A Before-After Study

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 237 (actual)
• Sponsor: Hospital Israelita Albert Einstein · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

BACKGROUND: Perioperative bleeding and transfusion are important causes of morbidity and mortality in patients undergoing liver transplantation. The aim of this study is to assess whether viscoelastic tests-guided therapy with the use of synthetic factor concentrates impact transfusion rates of hemocomponents in adult patients undergoing liver transplantation. METHODS: This is an interventional before-after comparative study. Patients undergoing liver transplantation before the implementation of a protocol using thromboelastometry and synthetic factor concentrates were compared to patients after the implementation. Primary outcome was transfusion of any hemocomponents. Secondary outcomes included: transfusion of red blood cells (RBC), fresh frozen plasma (FFP), cryoprecipitate or platelets, clinical complications, length of stay and in-hospital mortality.

Conditions

• Liver Transplant; Complications
• Bleeding
• Hemostatic Disorder

Interventions

Type	Name	Description
OTHER	Usual Care	Treatment of Coagulation Disorders Using Standard Coagulation Tests and Blood Components
OTHER	Thromboelastometry-Guided Therapy with Synthetic Factor Concentrates	Thromboelastometry-Guided Treatment of Coagulation Disorders Using Synthetic Factor Concentrates

Timeline

• Start date: 2007-01-01
• Primary completion: 2015-10-30
• Completion: 2018-01-01
• First posted: 2018-11-28
• Last updated: 2018-11-28