NCT03753191

The Effects of Transcranial Direct Current Stimulation on Executive Function in People With Mild to Moderate Dementia

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 80 (estimated)
• Sponsor: The Hong Kong Polytechnic University · Academic / Other
• Sex: All
• Age: 65 Years – 90 Years
• Healthy volunteers: Accepted

Summary

To study the effects of transcranial direct current stimulation on executive function in people with mild to moderate dementia

Detailed description

Extensive research had shown executive dysfunction in people with dementia (PWD) is associated with functional abnormalities in prefrontal regions such as the right inferior frontal gyrus (Right IFG) or the left dorsal lateral pre-frontal cortex (Left DLPFC) . Clinical studies suggest that tDCS may be a useful therapeutic tool. Post-tDCS improvements have also been shown in visuo-motor coordination of healthy controls and performance in working memory. The aim of this study is to investigate the effect of tDCS stimulation over left DLPFC or right IFG on attention, inhibition and working memory and their neural correlates in people with dementia (PWD) and healthy controls (HC).This study is planned as a double-blinded, randomized case-control interventional study with a duration of 30 months.

Conditions

• Dementia
• Executive Function
• Transcranial Direct Current Stimulation

Interventions

Type	Name	Description
DEVICE	transcranial direct current stimulation	Each subject will undergo one tDCS stimulation session lasting for 20 minutes. A constant current of 2 mA will be applied with a linear fade in, fade out of 10 seconds to prevent electrical transients.

Timeline

• Start date: 2019-06-01
• Primary completion: 2020-12-30
• Completion: 2021-10-20
• First posted: 2018-11-26
• Last updated: 2020-10-22

Locations

1 site across 1 country: Hong Kong