NCT03752021

The Endocannabinoid System in Human Gestational Tissues in Labor

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 20 (actual)
• Sponsor: Wake Forest University Health Sciences · Academic / Other
• Sex: Female
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

The purpose of this research study is to determine if the endocannabinoid (a biological system) plays a role in the labor process.

Detailed description

This is a pilot study to determine the feasibility of identification and quantification of various components of the endocannabinoid system in the labored versus non-labored myometrium, placenta and gestational membranes.

Conditions

• Labor

Interventions

Type	Name	Description
PROCEDURE	Myometrial Sampling	A myometrial sample will be obtained at the time of cesarean delivery. Sample will be obtained from the superior edge of the existing lower uterine segment incision and will be 2 inches in length and 0.5 inches in width. The uterine incision will be repaired in a standard two-layer closure. If a classical cesarean (vertical) uterine incision is deemed necessary and is performed by the surgical team, a sample of the same size will be taken parallel to the incision at the existing edge. The classical uterine incision will be closed utilizing the standard layered technique. Placenta and gestational membrane tissue will be obtained after placental delivery. The entire placenta and attached gestational membranes will be collected if not being sent for pathologic review

Timeline

• Start date: 2019-01-25
• Primary completion: 2019-07-01
• Completion: 2019-07-01
• First posted: 2018-11-23
• Last updated: 2019-08-15

Locations

2 sites across 1 country: United States