Trials / Active Not Recruiting
Active Not RecruitingNCT03747627
BPF Genetics of ILD Study
British Pigeon Fanciers Genetics of Interstitial Lung Disease Study
- Status
- Active Not Recruiting
- Phase
- —
- Study type
- Observational
- Enrollment
- 475 (actual)
- Sponsor
- University of Dundee · Academic / Other
- Sex
- All
- Age
- 18 Years – 80 Years
- Healthy volunteers
- Accepted
Summary
The investigators aim to examine the genetic determinants of interstitial lung disease in a cohort of subjects with regular exposure to pigeons, a known cause of one form of interstitial lung disease known as hypersensitivity pneumonitis. In addition we will examine immunological causes for hypersensitivity pneumonitis in this group. We anticipate our work will provide insights of use to clinicians and patients with hypersensitivity pneumonitis and other interstitial lung diseases.
Detailed description
The investigators aim to recruit participants with regular racing pigeon exposure at national (UK) and regional pigeon fancier meetings. Consenting subjects will complete questionnaires, provide blood samples for genetic analysis and immunological testing and undertake lung function measurements. Subjects will be observed, and encouraged to report referral to specialist respiratory services, and following this information will be sought on diagnosis (including supporting evidence). Where interstitial lung disease is detected this will be linked to subsequent unbiased analysis to detect potential predisposing genetic associations.
Conditions
- Lung; Disease, Interstitial, With Fibrosis
- Alveolitis, Extrinsic Allergic
- Bird Fancier's Lung
- Idiopathic Interstitial Pneumonias
- Lung Diseases, Interstitial
- Idiopathic Pulmonary Fibrosis
Interventions
| Type | Name | Description |
|---|---|---|
| DIAGNOSTIC_TEST | Genetic profiling | All participating subjects will undergo detailed genetic analysis, with the aim of detecting novel genetic drivers for the development of interstitial lung disease in the context of known sensitising agent (pigeon antigen) |
Timeline
- Start date
- 2019-01-19
- Primary completion
- 2025-01-19
- Completion
- 2028-01-01
- First posted
- 2018-11-20
- Last updated
- 2025-04-25
Locations
2 sites across 1 country: United Kingdom
Source: ClinicalTrials.gov record NCT03747627. Inclusion in this directory is not an endorsement.