NCT03737071

The Effects of Low Carbohydrate Diet on Liver Fat Content and Mitochondrial Fluxes

• Status: Active Not Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 10 (estimated)
• Sponsor: Helsinki University Central Hospital · Academic / Other
• Sex: All
• Age: 18 Years – 70 Years
• Healthy volunteers: Accepted

Summary

The purpose of this study is to examine whether a low carbohydrate diet as compared to simple calorie restriction decreases hepatic lipid content and changes hepatic mitochondrial flux in humans.

Detailed description

In this study, the investigators will examine whether a low carbohydrate diet as compared to simple calorie restriction will change hepatic lipid content and mitochondrial flux in humans. Before and after a low carbohydrate diet and a simple calorie restriction intervention, rates of hepatic mitochondrial flux will be assessed using positional isotopomer analysis of 3-13C-lactate during a 3 hour basal period. Rates of whole body ketogenesis will be determined using \[13C4\]β-hydroxybutyrate, and whole body glucose metabolism will be measured using \[2H7\]glucose. Body composition will be determined with bioelectrical impedance; hepatic lipid content will be measured with MRS. Whole-body oxidation of lipids, carbohydrates and protein will be determined using indirect calorimetry.

Conditions

• Fatty Liver

Interventions

Type	Name	Description
BEHAVIORAL	Low Carbohydrate Diet	Ketogenic dietary intervention
BEHAVIORAL	Simple Calorie Restriction Diet	Simple calorie restriction dietary intervention

Timeline

• Start date: 2018-11-15
• Primary completion: 2024-07-01
• Completion: 2024-08-01
• First posted: 2018-11-09
• Last updated: 2024-07-24

Locations

1 site across 1 country: Finland