NCT03736642

Study of the Microbiological Profile of Stool in Patients With Anorexia Nervosa

• Status: Withdrawn
• Phase: —
• Study type: Observational
• Enrollment: 0 (actual)
• Sponsor: Centre Hospitalier Universitaire de Saint Etienne · Academic / Other
• Sex: Female
• Age: 18 Years – 30 Years
• Healthy volunteers: Accepted

Summary

Anorexia nervosa is an eating disorder whose symptomatology induces a modification of the intestinal microbiota. To date, studies have shown variable profiles without linking them to metabolic and neuropsychological energy phenotyping. This intestinal dysbiosis could be involved in the maintenance of the disorders. Bidirectional communication channels exist between the microbiota, the intestine and the brain. Anomalies in these pathways could explain the impact of the microbiota on the pathophysiology of anorexia nervosa. Therapeutic interventions would then be possible to restore the microbiota in anorexia nervosa and influence the treatment of this disease. This study aims to explore the hypothesis of disruption of the microbiota-intestinal-brain axis transversely and measuring the intestinal microbiota, urinary metabolome, biological factors nutritional, immunological and physiological plasma plasma of the intestine, and finally, the psychological dimensions characteristic of anorexia nervosa.

Conditions

• Anorexia Nervosa
• Eating Disorder

Interventions

Type	Name	Description
BIOLOGICAL	blood sampling	12 ml sample
OTHER	stool sampling	20 g sample
OTHER	urine sampling	18 ml sample
DIAGNOSTIC_TEST	neuropsychological tests	* Go-nogo * flexibility * food stroop * implicit and explicit evaluation * Child Depression Inventory * Hamilton Depression Rating Scale

Timeline

• Start date: 2019-05-15
• Primary completion: 2019-05-15
• Completion: 2019-05-15
• First posted: 2018-11-09
• Last updated: 2020-07-30

Locations

1 site across 1 country: France