Trials / Completed
CompletedNCT03734783
IL-35+Breg/Il-35 Effect on T Cell Immune in Patients With CHB
Regulate Effect of Il-35 Secreting Breg Cells on Tcells and on Diseases Progression in Patients With CHB
- Status
- Completed
- Phase
- —
- Study type
- Observational
- Enrollment
- 55 (actual)
- Sponsor
- Changhai Hospital · Academic / Other
- Sex
- All
- Age
- 17 Years – 70 Years
- Healthy volunteers
- Accepted
Summary
The investigators observed the level of IL-35 secreting B regulatory (IL-35+Bregs) cells in peripheral blood cells in patients with chronic hepatitis B, and analysed the relationship between the IL-35+Bregs level and disease stage, and Th1 and Th2 cells level.
Detailed description
Regulatory B cells (Bregs) are involved in the immune tolerance process through multiple pathways and Bregs are involved in the process of chronic HBV infection. Here the investigators intended to investigate the regulating role and the mechanism of CD19+ IL-35+ cells on host T cell immune during chronic HBV infection by using in vitro cell sorting, B cell differentiation induction, Transwell cell co-culture system and other methods.
Conditions
Timeline
- Start date
- 2017-07-01
- Primary completion
- 2019-11-15
- Completion
- 2019-11-15
- First posted
- 2018-11-08
- Last updated
- 2019-11-18
Locations
1 site across 1 country: China
Source: ClinicalTrials.gov record NCT03734783. Inclusion in this directory is not an endorsement.