Trials / Completed
CompletedNCT03732651
The Impact of Non-pulsatile Blood Flow on CO2-Reactivity
The Impact of Non-pulsatile Perfusion on Cerebral Blood Flow and Brain Oxygenation
- Status
- Completed
- Phase
- N/A
- Study type
- Interventional
- Enrollment
- 32 (actual)
- Sponsor
- Medical University of Vienna · Academic / Other
- Sex
- All
- Age
- 15 Years – 75 Years
- Healthy volunteers
- Not accepted
Summary
The investigators hypothezised that CO2-reactivity of cerebral vessels is affected by systemic non-pulsatile blood flow. Patients undergoing elective cardiac surgery with CPB were enrolled in this prospective case control study. Blood flow velocity in the middle cerebral artery as well as regional cerebral oxygenation was determined during step changes of PaCO2 between 30, 40, and 50 mmHg. Measurements were conducted intraoperatively during non-pulsatile as well as postoperatively after admission to the ICU under pulsatile blood flow.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| PROCEDURE | alteration of PaCO2 level | step changes between 30, 40 and 50 mmHg |
Timeline
- Start date
- 2008-06-11
- Primary completion
- 2012-10-11
- Completion
- 2013-12-02
- First posted
- 2018-11-06
- Last updated
- 2018-11-06
Locations
1 site across 1 country: Austria
Source: ClinicalTrials.gov record NCT03732651. Inclusion in this directory is not an endorsement.