NCT03729934

Ketones Supplementation and Postprandial Lipemia

Effects of Ketones Supplementation on Postprandial Lipemia

• Status: Withdrawn
• Phase: N/A
• Study type: Interventional
• Enrollment: 0 (actual)
• Sponsor: University of Alabama at Birmingham · Academic / Other
• Sex: Male
• Age: 25 Years – 45 Years
• Healthy volunteers: Accepted

Summary

This study determines whether different forms of ketones supplemented prior to a meal lower the triglyceride (fat) content in the blood of overweight and obese individuals. Through a randomized crossover design, participants (n=15) will participate in each of the following three experimental groups (no treatment control, ketone ester, ketone salt), with a 5-14 day washout period between each experimental visit.

Detailed description

Previous studies conducted by the investigative team in rodents show that male mice fed a diet containing 30% ketone ester (by kcals) results in greater fecal content and energy loss. While the investigators are unsure of the exact macronutrient content of the energy loss, the hypothesis is that the energy excretion is attributed to lower fat absorption. In the context of this study, it's hypothesized that ketone salts and ketone esters (both available commercially and used for a variety of health-related claims) will reduce the absorption of dietary fats leading to lower circulating triglyceride concentrations if consumed prior to a high-fat mixed meal. If the hypothesis is correct, ketones supplementation could become a valuable strategy to reduce the rise in circulating triglycerides often present in obesity. Triglyceride concentrations in the blood following a meal have been linked to development of cardiovascular disease.

Conditions

• Obesity
• Overweight and Obesity
• Overweight
• Triglycerides High

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Ketone Ester	This arm receives 25 g ketone ester.
DIETARY_SUPPLEMENT	Ketone Salt	This arm receives 25 g ketone salt.

Timeline

• Start date: 2020-12-01
• Primary completion: 2021-01-01
• Completion: 2021-01-01
• First posted: 2018-11-05
• Last updated: 2021-05-04