NCT03728075

Neuromuscular Electrical Stimulation in Chronic Heart Failure Patient

The Role of Neuromuscular Electrical Stimulation in Regulation of Serum IL-6 and IL-15 in Chronic Heart Failure Patients

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 30 (actual)
• Sponsor: Dr. Soetomo General Hospital · Other Government
• Sex: All
• Age: —
• Healthy volunteers: Not accepted

Summary

The purpose of the study is investigate the effects of NMES in regulation of serum IL-6 and IL-15 in chronic heart failure patients who received standard inpatient cardiac rehabilitation protocol

Detailed description

Majority of chronic heart failure patients became intolerance of physical training that could limit activity. Recent studies reported that Neuromuscular electrical stimulation (NMES) application could increase muscle mass, oxidative enzyme, endothelial function, VO2 peak and quality of life in chronic heart failure patient. It was hypothesized that Neuromuscular Electrical Stimulation (NMES) assisted muscle contraction in chronic heart failure patients will increase the activity of myokine (Interleukin-6 and Interleukin-15), that in turn will promote exercise tolerance in this patient. the aim of this study was to investigate the effects of NMES in regulation of serum IL-6 and IL-15 in chronic heart failure patients who received standard inpatient cardiac rehabilitation protocol. Thirty chronic heart failure patients in cardiology ward that fulfilled inclusion criteria were randomized in two groups; the control group (standard inpatient cardiac rehabilitation protocol) and the intervention group (standard inpatient cardiac rehabilitation protocol and NMES). The intervention was done every day for seven days. Measurement of serum IL-6 and IL-15 were done before and after study, and analyzed by sandwich immunoassay with monoclonal antibody.

Conditions

• Chronic Heart Failure

Interventions

Type	Name	Description
DEVICE	Neuromuscular electrical stimulation (NMES)	NMES was placed on the quadriceps muscle of both legs

Timeline

• Start date: 2017-01-21
• Primary completion: 2017-03-29
• Completion: 2017-03-29
• First posted: 2018-11-01
• Last updated: 2018-11-01

Locations

1 site across 1 country: Indonesia