NCT03727360

Exercise for Brain Health in the Fight Against Alzheimer's Disease

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 124 (actual)
• Sponsor: University of Maryland, College Park · Academic / Other
• Sex: All
• Age: 60 Years – 80 Years
• Healthy volunteers: Accepted

Summary

The investigators aim to compare the effects of a 6-month moderate intensity exercise training (ET) intervention to a low intensity flexibility exercise control condition (FC) on brain function, cognition, and physical function in cognitively healthy and physically inactive older adults (ages 60-80). Apolipoprotein E epsilon4 (APOE-ε4) allele carriers are known to be at substantially greater risk for cognitive decline and Alzheimer's disease (AD). Cognitively intact APOE-ε4 allele carriers, and non-carriers, will be randomly assigned to 6-months of either supervised moderate intensity aerobic exercise training (ET) or supervised flexibility exercise control (FC). The ET and FC each contain a group based exercise component and are run in local retirement communities near College Park, MD, or on the University of Maryland College Park campus. The primary aims of the study are to compare pre-intervention to post-intervention changes in episodic memory performance and MRI biomarkers.

Conditions

• Healthy Cognition

Interventions

Type	Name	Description
OTHER	Exercise Training	Supervised exercise conducted four days per week for six months.
OTHER	Flexibility Control	Supervised exercise conducted four days per week for six months.

Timeline

• Start date: 2018-10-08
• Primary completion: 2024-04-30
• Completion: 2024-04-30
• First posted: 2018-11-01
• Last updated: 2024-06-06

Locations

1 site across 1 country: United States