NCT03725709

Metabolomic Profiling of in Patients With type2 Diabetes

Metabolomic Profiling of Cerebrospinal Fluid and Plasma in Patients With type2 Diabetes

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 68 (actual)
• Sponsor: Chang Gung Memorial Hospital · Academic / Other
• Sex: All
• Age: 20 Years – 75 Years
• Healthy volunteers: Accepted

Summary

To exam the metabolomic profiling of CSF and plasma in diabetes and establish the human CSF Metabolome Database of Type 2 DM.

Detailed description

Human cerebral spinal fluid (CSF) is known to be a rich source of small molecule biomarkers for central neurological and neurodegenerative diseases. However, the metaboloic bases of CSF in diabetes patient have not been studied. In this plan, the investigators will use analytical platforms, including nuclear magnetic resonance (NMR), liquid chromatography-mass spectrometry (LC-MS), to perform quantitative metabolomics on human CSF and blood samples and further establish the human CSF Metabolome Database of DM. This work will can supply important CSF metabolic profit information and help to facilitate a wide range of metabolomic studies on central nervous system diseases and their associations disease.

Conditions

• Diagnoses Disease
• Diabetes Mellitus, Type 2

Interventions

Type	Name	Description
PROCEDURE	spinal anesthesia	Plan to enroll 120 Type 2 diabetes and 120 non-diabetes patients with received spinal anesthesia.Blood will be collected at time point of pre-anesthesia 10 minutes and CSF samples will be collected at time point during spinal anesthesia induction. Blood will be collected, drawn into EDTA-coated tube.

Timeline

• Start date: 2016-08-01
• Primary completion: 2019-07-31
• Completion: 2019-07-31
• First posted: 2018-10-31
• Last updated: 2020-01-31

Locations

1 site across 1 country: Taiwan