NCT03722979

Study of the Expression of Endoplasmic Reticulum Stress During Extracorporeal Circulation in Humans

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 53 (actual)
• Sponsor: University Hospital, Rouen · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The links between systemic inflammation, endothelial dysfunction and endoplasmic reticulum (ER) stress in pre-clinical models make it an interesting potential therapeutic target, but there are no data describing SRE during severe inflammation in humans . For an approach to the study of SRE in humans in a situation of systemic inflammation, the analysis of patients benefiting from an extra-corporeal circulation for a programmed cardiac surgery would allow a study under well described conditions of inflammation, standardized, with the possibility for each patient to be his own witness. Compared to a situation of secondary inflammation (sepsis, acute pancreatitis, trauma ...) the analysis of the patients under CEC allows more precise description of the kinetics of the activation of the SRE because the beginning of the inflammatory mechanism is known with precision.

Conditions

• Cardiac Surgery

Interventions

Type	Name	Description
PROCEDURE	Cardiac surgery	The study will enroll patients having a planned cardiac surgery under extracorporeal circulation (CEC)

Timeline

• Start date: 2018-07-07
• Primary completion: 2019-03-06
• Completion: 2019-03-06
• First posted: 2018-10-29
• Last updated: 2026-04-17

Locations

1 site across 1 country: France