NCT03722355

Hyperfractionated RT With BCNU Versus Conventional RT With BCNU for Supratentorial Malignant Glioma

A Phase III Comparison of Hyperfractionated Radiation Therapy (RT) With BCNU and Conventional RT With BCNU for Supratentorial Malignant Glioma

• Status: Completed
• Phase: Phase 3
• Study type: Interventional
• Enrollment: 712 (actual)
• Sponsor: Radiation Therapy Oncology Group · Network
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Hyperfractionated radiation therapy (RT) to 72.0 Gy with BCNU will be compared to conventional radiation therapy to 60.0 Gy with BCNU to determine if hyperfractionated RT can improve the median survival time of adults with supratentorial malignant gliomas.

Conditions

• Glioma
• Glioblastoma Multiforme
• Astrocytoma

Interventions

Type	Name	Description
RADIATION	Conventional RT	Radiation therapy
RADIATION	Hyperfractionated RT	Radiation therapy
DRUG	Carmustine	Chemotherapy

Timeline

• Start date: 1990-11-09
• Primary completion: 1994-03-15
• Completion: 2002-10-18
• First posted: 2018-10-26
• Last updated: 2019-11-12