NCT03716531

Electron Beam Intraoperative Radiation Therapy Following Chemoradiation in Patients With Pancreatic Cancer With Vascular Involvement

PACER (Pancreatic AdenoCarcinoma With Electron Intraoperative Radiation Therapy): A Phase II Study of Electron Beam Intraoperative Radiation Therapy Following Chemoradiation in Patients With Pancreatic Cancer With Vascular Involvement

• Status: Active Not Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 199 (actual)
• Sponsor: Massachusetts General Hospital · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

This research study is studying an intervention as a possible treatment for pancreatic cancer.

Detailed description

In this research study, the investigators are researching how well IORT during surgery works in treating pancreatic cancer after 3-6 months of chemotherapy and external radiation therapy. IORT works by delivering radiation therapy to the tumor while reducing the amount of healthy tissue exposed to the radiation therapy. The investigators believe that the administration of IORT after 3-6 months of chemotherapy will help to stop the cancer cells from growing. The FDA (the U.S. Food and Drug Administration) has not approved IORT for this specific disease but it has been approved for other uses.

Conditions

• Pancreas Cancer

Interventions

Type	Name	Description
RADIATION	IORT	IORT works by delivering radiation therapy to the tumor while reducing the amount of healthy tissue exposed to the radiation therapy

Timeline

• Start date: 2019-03-19
• Primary completion: 2025-08-26
• Completion: 2027-12-31
• First posted: 2018-10-23
• Last updated: 2025-12-09

Locations

6 sites across 1 country: United States

Regulatory

• FDA-regulated device study