NCT03716128

Diagnosis of Renal Osteodystrophy in Patients With Reduced Renal Function

Diagnosis of Renal Osteodystrophy in Patients With Reduced Renal Function Can 18F-PET Replace Bone Histomorphometry

• Status: Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 40 (estimated)
• Sponsor: Ditte Hansen · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The aim of the study is to 1. To describe the bone morphology in patients with reduced renal function and high or low parathyroid hormone (PTH) respectively. 2. To investigate if the non-invasive method 18-Fluoride Positron Emission Tomography (18F-PET) can describe the bone turnover and reflect the bone histomorphologic changes 3. To investigate if non-oxidized PTH reflects bone turnover

Detailed description

Patients with reduced renal function and suspected high turnover or low turnover bone disease are recruited. A bone biopsy and a 18F-PET scan are performed and it is investigated if the 18F-PET can discriminate high turnover from low turnover bone disease

Conditions

• Renal Osteodystrophy

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	18F-PET	Bone biopsy and 18F-PET

Timeline

• Start date: 2018-09-26
• Primary completion: 2027-10-01
• Completion: 2027-10-01
• First posted: 2018-10-23
• Last updated: 2025-03-18

Locations

1 site across 1 country: Denmark