NCT03714438

Effect of Medicago Sativa on Oral Glucose Tolerance in Healthy Adults

Effect of Acute Administration of Medicago Sativa on Glucose Tolerance, Insulin Secretion and Insulin Sensitivity in Normoglycemic, Overweight Adults

• Status: Completed
• Phase: Phase 2
• Study type: Interventional
• Enrollment: 15 (actual)
• Sponsor: University of Guadalajara · Academic / Other
• Sex: All
• Age: 30 Years – 40 Years
• Healthy volunteers: Not accepted

Summary

Previous preclinical investigations have found that Medicago sativa promotes the decrease of glucose concentrations. To evaluate the acute effect of Medicago sativa administration on glucose tolerance, insulin secretion, and insulin sensitivity in healthy individuals.

Detailed description

A randomized, double-blind, placebo-controlled, two-period, cross-over clinical trail will be carrie out in 15 healthy, sedentary individuals of both genders, who meet the following inclusion criteria: 25 to 40 years of age, normal fasting plasma glucose (≤ 5.5 mm/L), blood pressure (\<130/90 mmHg), body mass index of 25 to 29.9 kg/m2, no taking any medication known to affect glucose tolerance, nondrinkers and nonsmokers. No pregnant, and lactation estate for female participants. They will be select from the same neighborhood and socioeconomic status. After a fasting blood sample patients will be assigned at random-order through a closed-envelope selection, to receive one of two possible sequences during which they received either single oral doses of Medicago sativa or homologated placebo in 1,500 mg and were crossover with a difference of at least 7 days washout interval. Thirty minutes after each intervention patients underwent a 75-g oral glucose tolerant test (OGTT). Area under the curve of glucose and insulin, phases of insulin secretion, and insulin sensitivity will be calculate for each treatment period.

Conditions

• Glucose Tolerance

Interventions

Type	Name	Description
DRUG	Medicago Sativa	Single oral doses of Medicago sativa (1,500 mg), 30 min before before the oral glucose tolerance test.
DIETARY_SUPPLEMENT	Placebo	Single oral doses of placebo (1,500 mg), 30 min before before the oral glucose tolerance test.

Timeline

• Start date: 2017-02-07
• Primary completion: 2018-01-11
• Completion: 2018-01-30
• First posted: 2018-10-22
• Last updated: 2019-02-21

Locations

1 site across 1 country: Mexico