NCT03712579

Impact of High-fat Meals Varying in Fatty Acid Composition on Adipose and Systemic Metabolic-inflammatory Responses

Impact of High-fat Meals Varying in Fatty Acid Composition on Adipose and Systemic Metabolic-inflammatory Responses: a Randomized Controlled Postprandial Study

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 8 (actual)
• Sponsor: Loughborough University · Academic / Other
• Sex: All
• Age: 18 Years – 50 Years
• Healthy volunteers: Accepted

Summary

Cardiometabolic disorders are a leading cause of death worldwide. Replacing saturated fatty acids (SFA) with unsaturated fatty acids is recommended as a way of lowering cardiometabolic disease risk. Consuming a diet rich in SFA may lead to a greater metabolic-inflammatory response in white adipose tissue during the fasting state, when compared to eating a diet rich in monounsaturated fatty acids (MUFA). Since individuals spend most of the day in the fed (or postprandial) state, it is important to see how different types of dietary fatty acids affect postprandial white adipose tissue and systemic metabolic-inflammatory responses. This study will investigate the effect of a SFA-rich meal on markers of white adipose tissue and systemic metabolic-inflammation, compared to a MUFA-rich meal in overweight adults. In a randomised, single blind controlled, cross-over manner participants will consume either a SFA- or MUFA-rich meal and sequential blood and white adipose tissue samples will be collected before and until 6 hours postprandially.

Conditions

• Inflammation
• Obesity
• Inflammatory Response
• Cardiovascular Diseases
• Overweight

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	SFA-Rich Meal	Saturated fatty acid-rich test meal, containing 75g test fat
DIETARY_SUPPLEMENT	MUFA-Rich Meal	Monounsaturated fatty acid-rich test meal, containing 75g test fat

Timeline

• Start date: 2019-01-21
• Primary completion: 2020-10-15
• Completion: 2020-10-15
• First posted: 2018-10-19
• Last updated: 2022-05-17

Locations

1 site across 1 country: United Kingdom