NCT03711383

Inulin and Acetate Production and Human Substrate Metabolism

The Effects of Inulin on Acetate Production and Human Substrate Metabolism

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 24 (actual)
• Sponsor: Maastricht University Medical Center · Academic / Other
• Sex: Male
• Age: 30 Years – 65 Years
• Healthy volunteers: Accepted

Summary

Based on our hypothesis that orally administered resistant starch and inulin/beta glucan will be fermented into a SCFA pattern high in acetate and that this will lead to beneficial effects on human substrate and energy metabolism, we aim to address the following primary objective: To investigate the effects of an acute administration of inulin/beta glucan in combination with resistant starch on fecal and plasma acetate, as well as on fasting and postprandial substrate and energy metabolism in lean normoglycemic men and obese, prediabetic men.

Conditions

• Obesity
• Pre Diabetes

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Inulin and Resistant Starch	12g per inulin in combination 7.5 g resistant starch per day the day before the CID Resistant starch 7.5 g
DIETARY_SUPPLEMENT	Inulin	12g per inulin in combination with maltodextrin per day the day before the CID
DIETARY_SUPPLEMENT	Placebo	isocaloric maltodextrin before test day

Timeline

• Start date: 2018-02-20
• Primary completion: 2018-11-15
• Completion: 2018-11-15
• First posted: 2018-10-18
• Last updated: 2020-01-14

Locations

1 site across 1 country: Netherlands