NCT03708913

Neuromodulation for Hypothalamic Obesity

Deep Brain Stimulation for Hypothalamic Obesity: A Surgical & Neuroimaging Study

• Status: Withdrawn
• Phase: N/A
• Study type: Interventional
• Enrollment: 0 (actual)
• Sponsor: University of British Columbia · Academic / Other
• Sex: All
• Age: 18 Years – 30 Years
• Healthy volunteers: Not accepted

Summary

The balance between hunger and satiety is imperative for an individual's survival and overall health.). Without this balance, individuals can become morbidly obese or lack adequate nutrition for survival. Craniopharyngioma (CP) is a benign tumour that occurs at the base of the brain in children. Unfortunately, pediatric neurosurgeons sometimes inadvertently destroy a child's satiety centre during CP tumour removal surgery. This leaves the child with a post-operative complication: an insatiable appetite. This form of obesity is called "hypothalamic obesity". This study is designed to investigate Deep Brain Stimulation for hypothalamic obesity in n=6 young adults who have stabilized tumours.

Detailed description

For young adults with destroyed satiety centres due to childhood CP surgery, we believe directly re-balancing the brain's control of hunger and satiety is necessary for sustained and long-term therapy. n=6 patients will be recruited in this Phase 1 DBS trial. The proposed research will hope to improve personal health among the young adults involved in this study by improving quality of life and avoiding long-term cardiovascular morbidities. Furthermore, this study will elucidate what brain regions drive excessive hunger and develop a treatment that attempts to reverse these abnormalities.

Conditions

• Craniopharyngioma
• Hypothalamic Obesity
• Metabolic Syndrome

Interventions

Type	Name	Description
DEVICE	Hypothalamic Deep Brain Stimulation	One-year continuous hypothalamic deep brain stimulation

Timeline

• Start date: 2019-06-01
• Primary completion: 2019-12-01
• Completion: 2020-04-01
• First posted: 2018-10-17
• Last updated: 2020-11-02

Locations

1 site across 1 country: Canada