NCT03708848

Tailored Therapy for Helicobacter Pylori Treatment in Patients With Penicillin Allergy

Antibiotic Susceptibility-based Tailored Therapy for Helicobacter Pylori Treatment in Patients With Penicillin Allergy: a Prospective Clinical Trial

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 112 (actual)
• Sponsor: Shanghai Jiao Tong University School of Medicine · Academic / Other
• Sex: All
• Age: 18 Years – 75 Years
• Healthy volunteers: Not accepted

Summary

Increasing drug resistance presents a significant challenge to the efficacies of common empiric eradication regimens for Helicobacter pylori treatment in the mainland of China. Tailored therapy may be the best choice to achieve good efficacy, especially in patients with penicillin allergy. Few studies had evaluated the patients with penicillin allergy.This study is designed to evaluate the efficacy and safety of antibiotic sensitivity-based tailored therapy for Helicobacter pylori treatment in the patients with penicillin allergy.

Conditions

• Helicobacter Pylori Infection

Interventions

Type	Name	Description
DRUG	Esomeprazole	Proton pump inhibitor
DRUG	Bismuth Potassium Citrate	Gastric mucosal protective drug with anti-H. pylori effect
DRUG	Clarithromycin	antibiotic for H. pylori eradication
DRUG	Metronidazole	antibiotic for H. pylori eradication
DRUG	Levofloxacin	antibiotic for H. pylori eradication
DRUG	Tetracycline	antibiotic for H. pylori eradication

Timeline

• Start date: 2018-12-05
• Primary completion: 2019-09-30
• Completion: 2019-09-30
• First posted: 2018-10-17
• Last updated: 2019-12-10

Locations

1 site across 1 country: China