Trials / Completed
CompletedNCT03705767
Placental Passage of Free and Esterified Phytosterols in Humans
The Maternal-fetal Gradient of Free and Esterified Phytosterols in Term Human Pregnancy at Delivery
- Status
- Completed
- Phase
- —
- Study type
- Observational
- Enrollment
- 68 (actual)
- Sponsor
- Università Politecnica delle Marche · Academic / Other
- Sex
- Female
- Age
- 20 Years – 40 Years
- Healthy volunteers
- Accepted
Summary
Total plasma cholesterol rises by 60 % with progressing pregnancy in humans. Because lipid-lowering drugs are contraindicated during pregnancy, natural compounds, such as phytosterols, may be a safe and effective alternative to prevent undesirable effects. Information on phytosterols in pregnancy is so far very limited. To date, to the best of our knowledge, no studies have characterized the maternal-fetal gradient of free and esterified phytosterols in full-term human pregnancy. For this purpose, maternal and cord blood cholesterol and non-cholesterol sterol (campesterol, stigmasterol, sitosterol) concentrations were measured in term pregnant women at delivery by using gas chromatography-mass spectrometry.
Conditions
Timeline
- Start date
- 2016-10-26
- Primary completion
- 2017-03-31
- Completion
- 2017-10-15
- First posted
- 2018-10-15
- Last updated
- 2018-10-15
Source: ClinicalTrials.gov record NCT03705767. Inclusion in this directory is not an endorsement.