NCT03703557

Isolation of Volatile Organic Compounds (VOCs) Related to the Olfactory Signature of Breast Cancer

Feasibility Study on the Possibility of Isolation of Volatile Organic Compounds (VOCs) Related to the Olfactory Signature of Breast Cancer

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 15 (actual)
• Sponsor: Institut Curie · Academic / Other
• Sex: Female
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

To ascertain the possibilities to isolate the breast cancer olfactive signature.

Detailed description

Patient recruitment during the first surgery consultation in Curie Institute. Odor sampling (non-invasive) with an odor-sensing polymer (Sorbstar® polymer developed especially for the trace level analysis), on: * The hands, before and after surgical excision of the tumor (friction of the hands) * The diseased breast, before and after surgical excision of the tumor (via a compress positioned on the breast for 1 night) * The tumor, during the surgical procedure (odor collection over a tumor sample). Each patient will be her own witness, before and after surgical excision, in an attempt to isolate the chemical signature tracks of breast cancer. The samples after surgery will be made after healing and before implementation of a treatment (chemotherapy and / or radiotherapy).

Conditions

• Breast Cancer
• Surgery

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	Sorbstar®	Thermodesorption method coupled with full two-dimensional gas chromatography and mass spectrometry.
DIAGNOSTIC_TEST	Odour sampling	Analyzed by the dogs of Curie Institute at the training centers

Timeline

• Start date: 2018-07-25
• Primary completion: 2019-09-20
• Completion: 2020-09-20
• First posted: 2018-10-12
• Last updated: 2020-12-22

Locations

1 site across 1 country: France