NCT03701828

Liver Health and Metabolic Function in People With Obesity

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 23 (actual)
• Sponsor: Washington University School of Medicine · Academic / Other
• Sex: All
• Age: 21 Years – 65 Years
• Healthy volunteers: Accepted

Summary

This project aims to determine the effect of significant weight loss on rates on hepatic fibrogenesis in people with obesity.

Detailed description

Non-alcoholic fatty liver disease (NAFLD) affects approximately 70% of those with obesity and if left untreated can progress to cirrhosis and liver failure. NAFLD stages progress from the stage of simple steatosis to steatohepatitis, and fibrosis The stage of NAFLD is currently best determined using histology from a liver biopsy, however this provides a static depiction of the state of the liver. Therefore, this project aims to determine fibrogenesis in the liver of obese humans in vivo, before and after weight loss.

Conditions

• Non-Alcoholic Fatty Liver Disease

Interventions

Type	Name	Description
PROCEDURE	Weight loss surgery	All surgery types will be included. However, only participants scheduled for surgery with collaborating surgeons will be included. Surgery is not provided by study team.

Timeline

• Start date: 2019-02-01
• Primary completion: 2024-02-19
• Completion: 2024-02-19
• First posted: 2018-10-10
• Last updated: 2025-06-19

Locations

1 site across 1 country: United States