NCT03699969

A Study Comparing Hypofractionated Dose Escalated VMAT to Conventional CCRT in Locally Advanced Head and Neck Cancer

A Clinical Study Comparing Hypofractionated Dose Escalated VMAT to Conventional CCRT in Locally Advanced Head and Neck Cancer

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 63 (actual)
• Sponsor: Cairo University · Academic / Other
• Sex: All
• Age: 18 Years – 70 Years
• Healthy volunteers: Not accepted

Summary

To compare efficacy and toxicity between hypofractionated dose escalated VMAT versus conventional concurrent chemoradiation in locally advanced head and neck cancer

Detailed description

patients were randomized to receive either: 70Gy in 35fx in 7wks at 2Gy/fx concurrently with weekly cisplatin 40mg/m2 (Arm A) or 74Gy in 33 fractions (fx) in 6.5 weeks at 2.24Gy/fx (Arm B). Volumetric Modulated Arc Therapy (VMAT) plans were created for both treatment arms

Conditions

• Locally Advanced Head and Neck Cancer

Interventions

Type	Name	Description
RADIATION	Hypofractionated dose escalated VMAT	measure the local control, progression free survival and overall survival

Timeline

• Start date: 2016-01-01
• Primary completion: 2018-10-01
• Completion: 2018-10-15
• First posted: 2018-10-09
• Last updated: 2018-10-11