NCT03698318

Pharmacokinetics Assessing Bioavailability of Gingerols and Shogaols of Five Ginger Extracts

Pharmacokinetics Study Assessing Bioavailability of Gingerols and Shogaols After Consumption of Five Ginger Extracts in Healthy Volunteers.

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 20 (actual)
• Sponsor: Givaudan France Naturals · Industry
• Sex: All
• Age: 18 Years – 55 Years
• Healthy volunteers: Accepted

Summary

The objective of this study is to assess bioavailability of total gingeroids, free gingerols and shogaols, so as their glucuronide and sulfate metabolites, in the plasma, after consumption of a single dose of 5 different ginger extracts. These five extracts have the same quantity of active substance but with different titration (1.6%, 5%, 39%, 26% and 26% NOP80).

Conditions

• Healthy Subject

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Tested product n°1	1 capsule (26% of gingerol/shogaol in 100 mg) to consume one time for each subject, at one experimental session (random assignment), with 250 mL of water (consumption at T0 time-point of the kinetic)
DIETARY_SUPPLEMENT	Tested product n°2	1 capsule (38.6% of gingerol/shogaol in 74.9 mg) to consume one time for each subject, at one experimental session (random assignment), with 250 mL of water (consumption at T0 time-point of the kinetic)
DIETARY_SUPPLEMENT	Tested product n°3	2 capsules (6.8% of gingerol/shogaol in 424.3 mg) to consume one time for each subject, at one experimental session (random assignment), with 250 mL of water (consumption at T0 time-point of the kinetic)
DIETARY_SUPPLEMENT	Tested product n°4	1 capsule (27% of gingerol/shogaol in 104.9 mg) to consume one time for each subject, at one experimental session (random assignment), with 250 mL of water (consumption at T0 time-point of the kinetic)
DIETARY_SUPPLEMENT	Tested product n°5	6 capsules (1.6% of gingerol/shogaol in 1806.25 mg) to consume one time for each subject, at one experimental session (random assignment), with 250 mL of water (consumption at T0 time-point of the kinetic)

Timeline

• Start date: 2018-10-15
• Primary completion: 2018-12-07
• Completion: 2018-12-07
• First posted: 2018-10-09
• Last updated: 2021-01-11

Locations

1 site across 1 country: France