Trials / Terminated
TerminatedNCT03698201
Blood Biomarker Signature in Glioma
Are Gliomas in Adults Associated With a Unique Identifying Blood Biomarker Signature?
- Status
- Terminated
- Phase
- —
- Study type
- Observational
- Enrollment
- 147 (actual)
- Sponsor
- Cancer Trials Ireland · Network
- Sex
- All
- Age
- 18 Years
- Healthy volunteers
- Not accepted
Summary
This is an exploratory, translational and non-interventional clinical study. The aim of this study is to identify a blood biomarker signature for glioma.
Detailed description
The identification of biomarkers (proteins, peptides and micro RNAs (miRNAs)) in the serum of patients with glioma would be a new, less invasive approach, which could help in the diagnosis of a glioma, and potentially help guide therapeutic decisions. The investigators will investigate the existence of biomarker profiles, which can * distinguish between low and high grade gliomas * correlate with patient outcomes including response to treatment and survival * indicate progression from a low to a high grade glioma. In this study the investigators collect and analyse blood samples taken from patients with suspected newly diagnosed grade II/III glioma or glioblastoma multiforme (GBM). Blood samples will be collected before any surgical intervention (resection or biopsy) and at various follow-up time points until progression or death. Based on the known natural history of gliomas (described above), it is planned to follow patients with grade III/IV tumours, who receive treatment, for up to 3 years and those with grade II-III tumours, (irrespective of treatment) for up to 5 years. Ultimately, the investigators envisage the translation of our observations into the hospital setting to aid the distinction between glioma grade II and grade III/IV.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| OTHER | Non-interventional | Translational, observational study |
Timeline
- Start date
- 2009-07-01
- Primary completion
- 2021-05-01
- Completion
- 2021-05-01
- First posted
- 2018-10-05
- Last updated
- 2025-07-08
Locations
1 site across 1 country: Ireland
Source: ClinicalTrials.gov record NCT03698201. Inclusion in this directory is not an endorsement.