NCT03697070

The INSPIRE-ASP PNA Trial

INtelligent Stewardship Prompts to Improve Real-time Empiric Antibiotic Selection for Patients With Pneumonia

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 44,780 (actual)
• Sponsor: Harvard Pilgrim Health Care · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The INSPIRE-ASP PNA trial is a cluster-randomized controlled trial of HCA hospitals comparing routine empiric antibiotic stewardship practices with real-time precision medicine computerized physician order entry smart prompts providing the probability that a non-critically ill adult admitted with PNA is infected with a resistant pathogen. Note: that enrolled "subjects" represents 59 individual HCA hospitals that have been randomized.

Conditions

• Pneumonia

Interventions

Type	Name	Description
OTHER	INSPIRE CPOE Smart Prompt	Quality improvement intervention: computerized physician order entry (CPOE) decision support alert that provides physicians with patient-specific risk estimate of having PNA due to a multidrug resistant organism (MDRO) and recommends appropriate antibiotic choice for non-ICU patients in the first 3 days of hospitalization. Continuation of other antibiotic stewardship activities in accordance with national standards.
OTHER	Routine Care	Routine Antibiotic Stewardship Arm - Continuation of all antibiotic stewardship activities in accordance with national standards.

Timeline

• Start date: 2018-10-01
• Primary completion: 2024-05-16
• Completion: 2024-05-16
• First posted: 2018-10-05
• Last updated: 2025-01-29
• Results posted: 2025-01-29

Locations

59 sites across 1 country: United States