NCT03696914

Intense Airway Eosinophilia in Asthma

Characteristics of the Eosinophilic Asthma Phenotype: an Observational Study in Patients From a Tertiary Care Center With Various Asthma Severities: The Quebec Heart and Lung Institute-Laval University Retrospective Asthma Database Analysis

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 918 (actual)
• Sponsor: Laval University · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

In asthma, the type and importance of the inflammatory response in the airways has allows identification of different phenotypes. Of these, one of the most common is eosinophilic asthma, based on induced sputum differential cell count. Patients with severe asthma and an eosinophilic asthma phenotype have different pathophysiological characteristics than those seen in patients with with mild asthma. However, few studies have compared patients with eosinophilic phenotype according to the severity of asthma. In addition, the stability of the phenotype based on the sputum results has been criticized. This study aims to describe the characteristics of patients with eosinophilic asthma phenotype according to the severity of asthma and determine the stability of the phenotype.

Detailed description

Characteristics of asthmatic subjects with sputum eosinophilia will be compared according to asthma severity.

Conditions

• Asthma
• Eosinophilic Asthma

Timeline

• Start date: 2017-06-06
• Primary completion: 2018-04-18
• Completion: 2018-08-03
• First posted: 2018-10-05
• Last updated: 2018-10-05

Locations

1 site across 1 country: Canada