NCT03695146

Heart Inflammation and Mental Stress Study

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 52 (actual)
• Sponsor: University of Miami · Academic / Other
• Sex: All
• Age: 21 Years – 65 Years
• Healthy volunteers: Accepted

Summary

The aim of the study is to investigate the neural underpinnings of cardiovascular reactivity to mental stress as a function of HIV and hypertensive risk.

Detailed description

The main objectives of the study are to assess (1) patterns of brain activity/connectivity that confers greater cardio-autonomic/emotion regulation, (e.g., heart rate variability, blood pressure reactivity, inflammatory-immune activation, etc.), during rest, mental stress, and anger-related distress, (2) whether changes in breathing pace mitigate task-based effects on cardio-autonomic-immune regulation, and (3) whether these patterns vary as a function of HIV or pre-hypertensive (HTN) status-related changes to the brain structures underlying cardioautonomic and emotion regulation.

Conditions

• Hypertension

Interventions

Type	Name	Description
BEHAVIORAL	Paced breathing	Individuals will be fitted with a respiratory transducer and receive auditory tones with which to pace their rate of inspiration and expiration in the experimental group.
BEHAVIORAL	Active relaxation	Individuals will be provided with headphones while resting quietly listening to relaxing tones/music.

Timeline

• Start date: 2019-08-19
• Primary completion: 2023-12-01
• Completion: 2023-12-22
• First posted: 2018-10-03
• Last updated: 2024-02-15

Locations

1 site across 1 country: United States