Trials / Unknown
UnknownNCT03695107
Clinical Study on the Effect of PTH on CYP3A4 Activity
- Status
- Unknown
- Phase
- —
- Study type
- Observational
- Enrollment
- 200 (estimated)
- Sponsor
- The Third Xiangya Hospital of Central South University · Academic / Other
- Sex
- All
- Age
- 18 Years
- Healthy volunteers
- Not accepted
Summary
Parathyroid hormone (PTH) may play an important role in the down-regulation of CYP3A4 expression induced by Chronic kidney diseases (CKD). In the study of molecular mechanism, the research group found that the expression of CYP3A2 metabolic enzyme in rat liver decreased in the state of CKD.And PTH may down-regulate the expression of CYP3A4 metabolic enzyme by inhibiting the expression of Nuclear factor- Kilobuse (NF-kB) p65 subunit
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| DRUG | Nifedipine controlled released tablets | lower blood pressure |
Timeline
- Start date
- 2019-10-02
- Primary completion
- 2020-09-10
- Completion
- 2020-09-10
- First posted
- 2018-10-03
- Last updated
- 2019-09-19
Locations
1 site across 1 country: China
Source: ClinicalTrials.gov record NCT03695107. Inclusion in this directory is not an endorsement.