NCT03695003

Cognitive Effects of Sage in Healthy Humans

The Acute and Chronic Cognitive Effects of a Sage Extract: a Randomized, Placebo Controlled Study in Healthy Humans

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 94 (actual)
• Sponsor: Northumbria University · Academic / Other
• Sex: All
• Age: 30 Years – 60 Years
• Healthy volunteers: Accepted

Summary

Extracts of sage and polyphenols have separately been reported to interact with central nervous system (CNS) mechanisms relevant to cognitive performance but, to date, no trial has combined these interventions. The current study investigates the effects of this combined intervention in N=90 healthy males and females between 30-60 yrs, at 600 mg versus placebo, on cognition and mood over a 29 day period.

Detailed description

Improved cognitive performance has been observed in humans following supplementation of sage extracts; including recall and mental arithmetic ability. Aspects of mood have also shown improvements; e.g. increased alertness, calmness and contentedness and reduced mental fatigue. These effects are believed to be underpinned by interactions with cholinergic and GABA pathways. Polyphenols too have shown promise in boosting cognition and mood and interaction with vasodilatory pathways and GABA neurotransmission are purported to be the likely mechanisms involved. Research has yet to investigate if a combination of sage terpenes and polyphenols could be even more efficacious via synergistic interaction.The current study investigates the effects of a 600 mg sage/polyphenol combination on cognition and mood in N=90 healthy male and female participants between the ages of 30-60 yrs acutely; on day 1 of supplementation, and chronically; after 29 days. Cognitive and mood data will also be collected every 7 days in the interim via a mobile phone cognitive task battery.

Conditions

• Cognitive Change
• Mood Change

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Cognivia	Cognivia is a trademarked sage/polyphenol combination dietary supplement from Nexira
DIETARY_SUPPLEMENT	Placebo	Placebo control capsules were prepared by Nexira also and are aesthetically identical to the Cognivia capsules

Timeline

• Start date: 2018-09-03
• Primary completion: 2019-09-24
• Completion: 2019-09-24
• First posted: 2018-10-03
• Last updated: 2020-03-17

Locations

1 site across 1 country: United Kingdom