Trials / Completed
CompletedNCT03690726
The Effects of rTMS in Rehabilitation Following Spinal Cord Injury
The Effects of Systematic, Repetitive Transcranial Magnetic Stimulation in Rehabilitation After Incomplete Spinal Cord Injury: Neuromuscular Adaptations and Recovery of Lower Limb Muscle Strength
- Status
- Completed
- Phase
- N/A
- Study type
- Interventional
- Enrollment
- 19 (actual)
- Sponsor
- Spinal Cord Injury Centre of Western Denmark · Academic / Other
- Sex
- All
- Age
- 18 Years – 80 Years
- Healthy volunteers
- Not accepted
Summary
The project will investigate whether repetitive transcranial magnetic stimulation (rTMS) can be used to potentiate/prime spinal cord injured patients' nervous systems for more intense rehabilitation exercise of longer duration - thus leading to greater recovery of motion function. The technique, in which a magnetic coil is positioned above the scalp and forms a magnetic field that activates the desired center of the brain (eg motor cortex), is used in clinical practice for the treatment of a number of disorders. However, although a combination of rTMS and gait training in SCI patients previously has proven beneficial, it is unknown whether additional functional gains can be achieved by combining rTMS and supervised, high-intensity resistance training. In this project, 30 newly-admitted patients will be recruited and randomized to receive either active rTMS and strength training (n = 15) or sham (imitated) rTMS + strength training, in parallel with standard care. The investigators hypothesize that the active rTMS group will have superior gains in locomotor function and muscle mass, compared to the sham group.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| DEVICE | repetitive transcranial magnetic stimulation | Repetitive transcranial magnetic stimulation of the leg motor cortex, in combination with resistance training |
| OTHER | Sham stimulation | Imitated magnetic stimulation: An active coil will be activated under the subject's head, firing down into the mattress, while an inactive coil will be held over the scalp |
Timeline
- Start date
- 2019-01-02
- Primary completion
- 2020-08-01
- Completion
- 2020-08-01
- First posted
- 2018-10-01
- Last updated
- 2020-12-29
Locations
1 site across 1 country: Denmark
Source: ClinicalTrials.gov record NCT03690726. Inclusion in this directory is not an endorsement.