NCT03689517

Placebo Modulation of Orthodontic Pain

Placebo Modulation of Orthodontic Pain: a Single-blind Functional MRI Study

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 23 (actual)
• Sponsor: West China Hospital · Academic / Other
• Sex: Female
• Age: 20 Years – 25 Years
• Healthy volunteers: Accepted

Summary

How placebo modulates orthodontic pain remains largely unknown. The present study aimed to investigate the placebo modulation of brain activity associated with orthodontic pain using fMRI.

Detailed description

How placebo modulates orthodontic pain remains largely unknown. The present study aimed to investigate the placebo modulation of brain activity associated with orthodontic pain using fMRI. 23 voluneers were recruited in a longitudinal fMRI experiment. At both the baseline and the one-month follow-up, orthodontic separators were placed between right lower molars 24 hours before MRI scans. At baseline, the subjects were scanned without placebo while all subjects took placebos half an hour before the scan at follow-up. Scans include a bite/non-bite task fMRI and a followed resting state fMRI. A generalized linear model was used to identify pain-regulating network from task fMRI, and functional connectivity analysis of pain related brain regions was performed to study the possible modulation of placebo on connectivity of pain-regulating networks using resting-state fMRI.

Conditions

• Pain

Interventions

Type	Name	Description
OTHER	placebo	participants took placebos (pills made by starch) that were told to be an effective analgesic.
DEVICE	orthodontic elastic separators	Orthodontic pain was introduced by placement of orthodontic elastic separators to the mesial and distal sides of the right mandibular first molar.

Timeline

• Start date: 2014-08-07
• Primary completion: 2016-07-08
• Completion: 2016-12-07
• First posted: 2018-09-28
• Last updated: 2018-09-28