NCT03688269

Minimal Effective Concentration (EC90) of Ropivacaine

Determination of the Minimal Effective Concentration (EC90) of Ropivacaine in Axillary Brachial Plexus Block With Intravenous Dexamethasone or Saline Injection

• Status: Completed
• Phase: Phase 3
• Study type: Interventional
• Enrollment: 146 (actual)
• Sponsor: Centre Hospitalier Universitaire de Besancon · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Prospective up and down sequential evaluation of the minimal effective concentration of perineural ropivacaine for 90% success in axillary brachial plexus block with the injection of intravenous dexamethasone or saline placebo during regional anesthesia performance

Detailed description

ropivacaine concentration determined by up and down sequential method dexamethasone or saline placebo determined by randomisation

Conditions

• Anesthesia, Conduction
• Ropivacaine
• Dexamethasone
• Axillary Brachial Plexus Block

Interventions

Type	Name	Description
DRUG	Intravenous dexamethasone	Intravenous injection of 8mg/2ml dexamethasone
DRUG	Intravenous saline	Intravenous injection of 2ml Saline 0.9%
DRUG	Perineural ropivacaine	Perineural injection of 20ml ropivacaine with adjustment of the concentration determined by sequential up and down method

Timeline

• Start date: 2018-10-05
• Primary completion: 2019-11-04
• Completion: 2020-05-04
• First posted: 2018-09-28
• Last updated: 2020-12-21

Locations

1 site across 1 country: France