NCT03686423

Reversing Diabetic Peripheral Neuropathy Through Exercise

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 44 (actual)
• Sponsor: NYU Langone Health · Academic / Other
• Sex: All
• Age: 40 Years – 70 Years
• Healthy volunteers: Not accepted

Summary

This project proposes a longitudinal design that uses multinuclear-MRI to evaluate the mechanistic effects of exercise on skeletal muscle function and peripheral nerve integrity in patients with diabetic peripheral neuropathy (DPN), and to determine whether exercise can reverse DPN symptoms. The investigators will prescribe a 10-week exercise program to 40 DPN patients. The investigators will acquire multinuclear-MRI data before and after the intervention that can provide mechanistic insight into the adaptations in lower leg muscle function and peripheral nerve integrity of patients with DPN, and their role in improving DPN symptoms following physical exercise intervention.

Conditions

• Peripheral Neuropathy
• Diabetes

Interventions

Type	Name	Description
PROCEDURE	Exercise Program	The exercise program will combine moderate intensity aerobic exercise with lower-extremity specific resistance training. A moderate level of intensity will be calculated based on results from a maximal graded exercise test (VO2R) conducted prior to the intervention.

Timeline

• Start date: 2018-11-28
• Primary completion: 2022-06-30
• Completion: 2022-06-30
• First posted: 2018-09-27
• Last updated: 2023-05-17
• Results posted: 2023-05-17

Locations

1 site across 1 country: United States