NCT03685396

Patient Morbidity After Palatal Free Gingival Grafts With or Without PRF Membranes Coverage

Patient Morbidity After Palatal Free Gingival Grafts With or Without PRF Membranes Coverage: a Comparative Randomized Clinical Trial

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 42 (actual)
• Sponsor: Azienda Ospedaliera San Paolo · Academic / Other
• Sex: All
• Age: 18 Years – 60 Years
• Healthy volunteers: Accepted

Summary

This study evaluates postoperative morbidity of patients that undergo free gingival graft harvesting from palate with or without use of autogenous PRF (Platelet Rich Fibrin) membranes to cover the donor site.In the Test Group venous blood sampling was done in order to prepare PRF membranes used to cover the donor site, whereas in Control Group hemostatic agents with oxidized and regenerated cellulosa were used.

Conditions

• Postoperative Pain
• Postoperative Complications
• Gingival Recession

Interventions

Type	Name	Description
BIOLOGICAL	Platelet rich fibrin ( PRF)	Venous blood was collected with a butterfly needle in two 10 mL tubes without anticoagulants or other chemicals. The tubes were immediately centrifuged at 3000 rpm for 10 minutes. At the end of centrifugation a fibrin clot (PRF) was obtained in the middle of the tube, just between the red corpuscles at the bottom and acellular plasma at the top. The PRF clot was taken from the tube and the red cells portion at the base of the clot was eliminated with sterile scissors Then the PRF was enveloped in sterile gauzes and positioned between two glass plates: the compression drove out the serum from the clot obtaining PRF membranes that were ready to be used in the surgical site.
DRUG	hemostatic agents with oxidized and regenerated cellulosa	In the Control Group hemostatic agents with oxidized and regenerated cellulosa were sutured to the palatal wound with mattress suture ( silk 5/0).

Timeline

• Start date: 2017-11-27
• Primary completion: 2018-07-23
• Completion: 2018-09-09
• First posted: 2018-09-26
• Last updated: 2019-08-05
• Results posted: 2019-08-05

Locations

1 site across 1 country: Italy