NCT03685032

Effects of Intraoperative Dexamethasone and Ondansetron on Postoperative Nausea and Vomiting in Microvascular Decompression Surgery

Effects of Intraoperative Dexamethasone and Ondansetron on Postoperative Nausea and Vomiting in Microvascular Decompression Surgery: A Randomized Controlled Study

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 54 (actual)
• Sponsor: Khon Kaen University · Academic / Other
• Sex: All
• Age: 18 Years – 75 Years
• Healthy volunteers: Not accepted

Summary

Postoperative nausea and vomiting (PONV) is a common problem and may lead to catastrophic complications, especially in neurosurgical cases. The aim of this study was to evaluate the effects of dexamethasone and ondansetron for preventing PONV in patients who underwent microvascular decompression surgery (MVD).

Detailed description

A prospective, double-blinded randomized control trial was conducted with 54 patients who underwent MVD. Patients were allocated into two groups. The study group (Gr. D) received intraoperative dexamethasone 4 mg iv and ondansetron 4 mg iv, whereas the control group (Gr. N) received placebo (0.9% normal saline 1 ml iv and 0.9% normal saline 2 ml iv). The incidence and severity of PONV were observed at 1, 2, 4 and 24 hr post-surgery.

Conditions

• Microvascular Decompression Surgery
• Postoperative Nausea and Vomiting

Interventions

Type	Name	Description
DRUG	Dexamethasone	The 4 mg of dexamethasone in 1 ml intravenous was administrated after patient received general anesthesia
DRUG	Ondansetron	The 4 mg of ondansetron in 2 ml intravenous was administrated at the end of the operation.
DRUG	0.9% Sodium Chloride Injection	The 0.9% sodium chloride in 1 ml intravenous was administrated after patient received general anesthesia. At the end of operation, the 0.9% sodium chloride in 2 ml intravenous was administrated.

Timeline

• Start date: 2014-08-07
• Primary completion: 2016-02-16
• Completion: 2016-02-16
• First posted: 2018-09-26
• Last updated: 2018-09-26

Locations

1 site across 1 country: Thailand