NCT03684109

Non-invasive Glioma Characterization Through Molecular Imaging

Pilot Study for Non-invasive Glioma Characterization Through Molecular Imaging

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 30 (estimated)
• Sponsor: University of Miami · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

MRI-based sequences can provide non-invasive quantification of intratumoral 2-hydroxyglutarate (2HG) distribution and tumor cellularity in human gliomas and help guide the development of novel glioma therapies.

Detailed description

This is a pilot study aiming at developing and optimizing MRI-based sequences to provide non-invasive quantification of intratumoral 2-hydroxyglutarate (2HG) distribution and tumor cellularity in human gliomas and help guide the development of novel glioma therapies.

Conditions

• Glioma
• Brain Tumor
• Primary Brain Tumor
• Malignant Glioma
• Malignant Primary Brain Tumor

Interventions

Type	Name	Description
DEVICE	3T MRI Scanner	3T MRI Scanner providing Mega-laser sequence for single-voxel Magnetic Resonance Spectroscopy (MRS) data for 2 hydroxyglutarate (2HG) quantitation.

Timeline

• Start date: 2019-01-25
• Primary completion: 2026-01-31
• Completion: 2026-01-31
• First posted: 2018-09-25
• Last updated: 2025-01-28

Locations

1 site across 1 country: United States

Regulatory

• FDA-regulated device study