NCT03680547

Nephropathy in Patients With Sickle Cell Disease

Pattern of Sickle Cell Nephropathy in Patients With Sickle Cell Disease

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 25 (estimated)
• Sponsor: Assiut University · Academic / Other
• Sex: All
• Age: 5 Months – 18 Years
• Healthy volunteers: Not accepted

Summary

There are some diseases that give rise to diverse renal manifestations as does sickle cell disease

Detailed description

Such involvement adversely affects virtually all major physiological processes in the kidney, and leads to complications that are common and chronic on the one hand (such as impaired urinary concentrating ability), and those that are rare and uniformly fatal on the other (such as renal medullary carcinoma) This steady adverse renal sequelae shortens the average lifespan of patients with SCD. Proteinuria and a reduced glomerular filtration rate are risk factors associated with increased mortality among those patients with approximately 16-18% of overall mortality in this patient group is due to kidney disease. Once end stage renal disease is reached, the mortality of patients who are on haemodialysis and have SCD is increased severalfold relative to the mortality of patients who are on haemodialysis but do not have SCD. Thus,although the average lifespan of patients with SCD has increased during recent decades owing to improved management of complications outside the kidney,kidney disease contributes substantially to the still increased mortality in SCD.

Conditions

• Sickle Cell Nephropathy

Interventions

Type	Name	Description
OTHER	patient with sickle cell disease	assess degree of renal affection in patientswith sickle cell disease attending Assuit university Children hospital by estimating some predictors of glomerular and tubular dysfunction.

Timeline

• Start date: 2020-05-01
• Primary completion: 2020-05-30
• Completion: 2021-01-01
• First posted: 2018-09-21
• Last updated: 2019-11-29