NCT03680144

Utility of Perfusion MRI to Detect Radiation Necrosis in Patients With Brain Metastases

Diagnostic Accuracy of Dynamic Susceptibility Contrast (DSC) Perfusion MRI to Determine Radiation Necrosis Versus Tumor Progression in Brain Metastases Treated With Stereotactic Radiosurgery

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 8 (actual)
• Sponsor: Emory University · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

This trial studies how well dynamic susceptibility contrast-magnetic resonance imaging (MRI) works in determining radiation necrosis and tumor progression in participants with cancer that has spread to the brain and are being treated with radiation therapy. Diagnostic procedures, such as dynamic susceptibility contrast-MRI, may improve the ability to determine indeterminate post-treatment changes seen on imaging after radiation therapy.

Detailed description

PRIMARY OBJECTIVE: I. To prospectively determine the sensitivity and specificity of dynamic susceptibility contrast (DSC)-MRI parameters in detecting tumor recurrence versus radiation necrosis for brain metastases treated with stereotactic radiosurgery (SRS). SECONDARY OBJECTIVES: I. To correlate radiographic diagnoses with pathologic diagnoses when surgical resection is clinically indicated. II. To correlate baseline relative cerebral blood volume (rCBV) values and other hemodynamic parameters with tumor primary histology. III. To assess overall survival, local failure, distant brain failure and neurologic death. OUTLINE: Participants undergo a diagnostic MRI with and without contrast and treatment planning DSC perfusion MRI series before receiving SRS at 4-6 weeks after SRS, and then every 3 months unless clinically indicated sooner.

Conditions

• Invasive Malignant Neoplasm
• Metastatic Malignant Neoplasm in the Brain

Interventions

Type	Name	Description
PROCEDURE	Dynamic Susceptibility Contrast-MRI (DSC-MRI)	Undergo DSC-MRI
PROCEDURE	Magnetic Resonance Imaging (MRI)	Undergo diagnostic MRI

Timeline

• Start date: 2018-11-28
• Primary completion: 2019-05-28
• Completion: 2019-05-28
• First posted: 2018-09-21
• Last updated: 2024-01-11

Locations

2 sites across 1 country: United States