NCT03679156

Retinal Pigment Epithelial Characteristics in Eyes With Neovascular Age-related Macular Degeneration Following Long-term Treatment With Anti Neovascular Endothelial Growth Factor

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 18 (actual)
• Sponsor: Hospital Hietzing · Academic / Other
• Sex: All
• Age: 66 Years – 98 Years
• Healthy volunteers: Not accepted

Summary

Purpose: To assess retinal pigment epithelial (RPE) and retinal structural changes in eyes with neovascular age-related macular degeneration (AMD) treated with anti-vascular endothelial growth factor (anti-VEGF) during long-term follow-up and to evaluate morphological markers potentially influencing prognosis. Methods: 18 patients (18 eyes) with neovascular AMD were recruited subsequent to completion the Avastin Versus Lucentis in Age Related Macular Degeneration (MANTA) study following a mean period of 84 months (range: 69-93 months). After receiving a loading dose of 3 intravitreal anti-VEGF injections subsequent to baseline of the MANTA study, patients were treated as-needed \[pro re nata (PRN)\]. Functional and morphological changes were assessed using spectral domain optical coherence tomography (SD-OCT).

Conditions

• Neovascular Age-related Macular Degeneration

Interventions

Type	Name	Description
DEVICE	OCT	Patients were recruited, visual acuity and optical coherence tomography Pictures were taken

Timeline

• Start date: 2016-05-30
• Primary completion: 2016-11-02
• Completion: 2017-04-15
• First posted: 2018-09-20
• Last updated: 2018-09-20