NCT03677817

Perioperative Lidocaine Administration in Thoracoscopic Surgery for Improved Postoperative Pain Control

Prospective, Randomized, Double Blind, Superiority Trial, Evaluating the Effect of Perioperative Lidocaine on Postoperative Opioid Consumption, Pain Ratings, Duration of Hospital Stay, Time to First Defecation, 30-day Mortality and Development of Chronic Pain in Patients Undergoing Video-assisted Thoracoscopic Procedures

• Status: Completed
• Phase: Phase 3
• Study type: Interventional
• Enrollment: 113 (actual)
• Sponsor: University Hospital, Basel, Switzerland · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Placebo-controlled study to analyze the effect of perioperative intravenous lidocaine administration on total morphine consumption (TMC) and on pain intensity in thoracoscopic surgery .

Detailed description

Thoracoscopy (thoracic surgery) is a video-assisted minimally invasive operation in thoracic surgery, which is associated with pain after surgery. Trial drug Lidocaine is approved as pain medication. This placebo-controlled study analyzes the effect of perioperative intravenous lidocaine administration on total morphine consumption (TMC) and on pain intensity in thoracoscopic surgery . Half of the patients will receive NaCl 0.9% (a saline solution without active ingredient) instead of Lidocaine.

Conditions

• Postoperative Pain

Interventions

Type	Name	Description
DRUG	Lidocaine	regimen of lidocaine administration of 1,5 mg/kg, IV bolus, followed by continuous infusion at 3,0 mg/kg/h
DRUG	NaCl 0,9%	IV bolus of NaCl 0,9%, followed by continuous infusion of NaCl 0,9%

Timeline

• Start date: 2019-04-03
• Primary completion: 2022-08-28
• Completion: 2022-08-28
• First posted: 2018-09-19
• Last updated: 2022-09-07

Locations

1 site across 1 country: Switzerland