NCT03677297

"Efficacy Of 1.2% Rosuvastatin Gel In The Management Of Infrabony Defects"

Comparative Evaluation of Treatment Of Infrabony Defects With and Without 1.2% Rosuvastatin Gel: In-Vivo Study

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 10 (actual)
• Sponsor: Dr. D. Y. Patil Dental College & Hospital · Academic / Other
• Sex: All
• Age: 30 Years – 50 Years
• Healthy volunteers: Accepted

Summary

Study aims to evaluate clinical and radiographic effectiveness of 1.2% Rosuvastatin gel in the treatment of Infrabony defects in chronic periodontitis patients.

Detailed description

Source from where the patients will be selected: 10 patients with chronic periodontitis having two or more infrabony defects will be selected from the Outpatient section of Dept. of Periodontology, Dr. D. Y. Patil Dental College and Hospital, Pimpri, Pune - 18. A detailed clinical examination, case history and written consent will be obtained from all the participants. Before surgery, each patient will be given careful instructions regarding proper oral hygiene measures. A full-mouth phase I therapy will be performed. A periodontal re-evaluation will be performed after 4 to 6 weeks of phase 1 therapy to confirm the desired sites for the study. The selected sites will be divided randomly by using a Sequentially numbered, opaque, sealed envelopes (SNOSE) randomization into control and test sites. The control site will be treated with Access Flap Surgery (AFS), whereas test sites will be treated with AFS and 1.2% Rosuvastatin gel. Suitable antibiotics and analgesics will be prescribed along with Chlorhexidine digluconate rinses (0.2%) twice daily for 14 days. Patients will be examined at 4 weeks, 3 and 6 month after surgery.

Conditions

• Adult Periodontitis

Interventions

Type	Name	Description
DRUG	Rosuvastatin	Test sites were treated with access flap surgery and 1.2% Rosuvastatin gel

Timeline

• Start date: 2016-01-28
• Primary completion: 2017-08-01
• Completion: 2017-11-10
• First posted: 2018-09-19
• Last updated: 2018-09-19

Locations

1 site across 1 country: India