NCT03676647

Diagnostic DNA Methylation Signature in Diagnosing Thyroid Cancer After Fine-Needle Aspiration in Patients With Thyroid Nodules

Retrospective-Prospective Collection of Thyroid Specimens After FNA

• Status: Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 22 (estimated)
• Sponsor: City of Hope Medical Center · Academic / Other
• Sex: All
• Age: 19 Years
• Healthy volunteers: Not accepted

Summary

This trial studies how well the diagnostic deoxyribonucleic acid (DNA) methylation signature works in detecting thyroid cancer in patients with thyroid nodules. Using diagnostic testing, such as the diagnostic DNA methylation signature, may be a less invasive way to check for thyroid cancer.

Detailed description

PRIMARY OBJECTIVES: I. To validate a novel epigenetic thyroid nodule diagnostic test, diagnostic DNA methylation signature (DDMS) in a retrospective-prospective study with leftover of fine needle aspiration biopsies. OUTLINE: Previously collected FNA aspiration specimen samples are analyzed via DDMS assay. Participants undergo FNA aspiration for collection of tissue samples for analysis via DDMS assay. After completion of study, patients are followed up yearly for 5 years.

Conditions

• Thyroid Gland Nodule

Interventions

Type	Name	Description
OTHER	Diagnostic DNA Methylation Signature	Undergo collection of tissue samples

Timeline

• Start date: 2026-04-25
• Primary completion: 2028-09-25
• Completion: 2028-09-25
• First posted: 2018-09-19
• Last updated: 2026-02-20

Locations

1 site across 1 country: United States